Shariant

Decoding the clinical significance of DNA variants is complex and challenging when clinical laboratories operate in silos. Sharing variant interpretations across laboratories improves accurate diagnoses and the management of patients’ health.

Shariant is a system for real-time national sharing of this vital data between Australian diagnostic laboratories. The rapid exchange of this key information allows genomic experts to decode the human genome with greater accuracy.

Importantly, it supports a process to automatically identify and resolve discrepancies in variant interpretation. Shariant also facilitates the sharing of variant interpretations internationally.

As of June 2025, Shariant has shared more than 39,000 prospective variant interpretations from 16 clinical genetic testing laboratories across five states. Shariant has also enabled over 11,000 submissions from laboratories to the international database, ClinVar, driving a 3000% increase in Australia’s international knowledge sharing.